The prognostic significance of most KMT2A fusions is not certain in childhood AML, but t(4;11)(q21;q23.3)/KMT2A-MLLT2, t(6;11)(q27;q23)/KMT2A-MLLT4, t(10;11)(p12;q23)/KMT2A-AF10, and t(10;11)(p11.2;q23)/KMT2A-ABI1 were identified with a poor prognosis in most of the literature [26]. The gene discussed is AFDN; the disease is acute myeloid leukemia.