Separately, the connection between upregulation and/or accumulation of TRAF6 and neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis (ALS) has been reported since TRAF6 triggers neuronal apoptosis and central nervous system (CNS) disruption. This evidence concerns the gene TRAF6 and early-onset autosomal dominant Alzheimer disease.