AKT1 and colonic neoplasm: As an upstream signaling pathway involved in the regulation of the cell cycle and apoptosis in colon cancer, the impact of compound 1t on the MET/PI3K/AKT/mTOR intracellular pathway was assessed which revealed that MET receptor tyrosine kinase and its downstreams were inhibited in a concentration-dependent manner, suggesting that MET receptor tyrosine kinase is the molecular target mediating the antiproliferative activity of compound 1t in HCT116 colon cancer cells.