For carbamazepine, in the same individual, well-known alleles (HLA-B*15:02, HLA-A*31:01) associated with severe skin reactions, such as Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), and HLA alleles (HLA-B*40:01, HLA-Cw*01:02, and HLADRB1*04:05 for SJS/TEN, HLA-B*15:01 for SJS/TEN, HLA-B*40:01 for SJS/TEN and drug reaction with eosinophilia and systemic symptoms (DRESS), HLA-B*46:01 for all the severe acute skin reactions) that are reported to confirm a certain degree of protection can be present at the same time [75]. This evidence concerns the gene HLA-B and skin reaction.