While the development and progression of oral squamous cell carcinoma (OSCC) are known to be driven via EGFR-HB-EGF and EGFR-EREG interactions [40,41,42] in OSCC cells, pain is associated with EREG- or HB-EGF-mediated activation of EGFR [19,43,44]. Here, EGFR is linked to oral cavity squamous cell carcinoma.