Furthermore, in N2A-EGFR cells (a neuroblastoma cell line expressing EGFR), the same group observed that chronic morphine administration led to increased EGFR phosphorylation and translocation to the endoplasmic reticulum, which was essential for posterior MOR-CRT (calreticulin) tethering, leading to increased AC5 activity [45]. Here, EGFR is linked to neuroblastoma.