Trypan blue and flow cytometry were used to investigate viability and cell cycle effects. Annexin V staining, rhodamine assay, and Western blotting were used to determine apoptosis induction and changes in protein expression. Efficacy of single drugs and combinations were tested in an adult T-cell leukemia (HuT-102) mouse xenograft model. This evidence concerns the gene ANXA5 and T-cell leukemia.