The prognostic value of pyroptosis-related genes with the top eight HR values in GBM patients in the high-/low-expression groups was 5.18 for CASP6, 5.17 for GBP1, 4.73 for CASP8, 4.24 for CASP4, 4.1 for GBP5, and 4.07 for GSDMD (Figure 2). The gene discussed is GSDMD; the disease is glioblastoma.