Signal transducer and activator of transcription 3 (STAT3) activation via IL-6 autocrine is associated with LEN-resistance, and bromodomain for CRBN binding protein/E1A binding protein p300 (CBP/EP300) inhibition can release LEN-refractoriness via the STAT3-activated myeloma cell line [33]. This evidence concerns the gene IL6 and plasma cell myeloma.