When considering endothelin-1, we observed significantly higher serum endothelin-1 levels in HFRS patients during the acute phase (median 3.1 pg/mL) and the convalescent phase (median 1.9 pg/mL) when compared to healthy individuals (median 1.2 pg/mL, p < 0.001, p < 0.001, respectively). The gene discussed is EDN1; the disease is hemorrhagic fever with renal syndrome.