Another study comparing acute effects of BRC on PRL levels in patients with hyperprolactinemic and normoprolactinemic PCOS demonstrated an inhibitory effect of DAs on LH levels only in PCOS women with concurrent HPRL, suggesting that a relative endogenous dopamine deficiency may be, in part, the cause of hypersecretion of PRL and LH in patients with hyperprolactinemic PCOS [118]. The gene discussed is PLOD1; the disease is polycystic ovary syndrome.