PPARG and obesity due to melanocortin 4 receptor deficiency: Zhu et al. found that Dubosiella can improve abnormal indexes in obese mice induced by a high-fat diet, reduce LDL-C, TG, and body weight, improve the digestion and absorption ability of glucose in mice, and reduce the expression levels of lipid metabolism genes such as CD36, FASN, and PPARγ in the liver, thereby alleviating the disorder of lipid metabolism caused by obesity [24].