GSK3B and infectious otitis media: In the present study, β-catenin, p-GSK-3β, and c-Myc, the downstream target genes of Wnt signaling, were overexpressed in the AOM/DSS group (Figure 8A–D), while APE and AFE were able to alleviate the overexpression of β-catenin, p-GSK-3β, and c-Myc in the colon of the AOM/DSS-treated mice in comparison with the model group.