The Western blotting results in Figure 5A,B show that AOM/DSS treatment decreased transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) expression and increased interleukin-6 (IL-6) expression in comparison with those of the control group, while APE treatment increased Nrf2 expression and decreased IL-6 expression, compared to the model group, which suggests that APE might downregulate the Nrf2-mediated expression of inflammatory mediators. The gene discussed is IL6; the disease is infectious otitis media.