The activation of MAPKs (including Erk, p38MAPK, and JNK), which has been proven to have a positive correlation with several inflammatory cytokines, including IL-6, is recognized as being able to interact with, expand, and integrate signals from various stimuli to regulate cellular proliferation, inflammatory responses, apoptosis, etc., and is critically involved in the development of IBD and CRC [36]. The gene discussed is MAPK8; the disease is colorectal carcinoma.