CXCL8 and gingivitis: On the other hand, we were not able to detect any impact of 14 days of oral hygiene neglect on the salivary IL-1β, IL-8, MIF, or MCP-1 levels in either the placebo or the probiotics groups (Table 2), which is contrary to our earlier study where IL-1β, IL-8, and MCP-1 decreased during experimental gingivitis [30].