PPARA and obesity due to melanocortin 4 receptor deficiency: Therefore, our data strongly suggest that the increase in muscle and liver of OEA, PEA and POEA, PPAR-α ligands, and the reduction in EC 2-AG, by enhancing the ratio between PPAR-α/EC system, might promote mitochondrial function and thereby improve glucose and lipid metabolism in dysmetabolic conditions such as obesity.