Interestingly, the levels and activities of Nrf2 are significantly reduced, whereas the nuclear translocation of NF-κB is significantly reduced in the livers of rats with NAFLD and when associated with hepatic steatosis, inflammation, oxidative damage, and fibrosis [84,85,86,87,88,89]. This evidence concerns the gene NFE2L2 and metabolic dysfunction-associated steatotic liver disease.