Notably, haplotype analysis in patients with colonic diverticulosis unveiled the frequent coexistence of alleles, such as MMP3 −1715 5A/5A (a genotype characterized by two alleles with high transcription activity), MMP9 −1562 C/C (a genotype featuring two alleles with low transcription activity), and MMP12 −82 A/A (a genotype with two alleles of high transcription activity). Here, MMP12 is linked to Colonic diverticula.