Among patients with diverticulosis, the most prevalent haplotypes included MMP3 −1715 5A/5A|MMP9 −1562 C/C|MMP12 −82 A/A (31%) and MMP3 −1715 5A/6A|MMP9 −1562 C/T|MMP12 −82 A/G (14%). Here, MMP12 is linked to diverticular disease.