Patients with colonic diverticulosis exhibited a notably higher prevalence of Allele T in MMP9 (rs3918242) and the 5A/5A genotype in MMP3 (rs3025058) when compared with their healthy counterparts; the findings suggest a role for the degradation of ECM proteins in the formation of colonic diverticulosis. The gene discussed is MMP3; the disease is Colonic diverticula.