In another anti-GBM animal model, the administration of rapamycin (sirolimus), which binds to the mammalian target of rapamycin (mTOR), inhibited cell proliferation signals and produced immunosuppressive effects, resulting in decreased proteinuria, reduced inflammatory cell infiltration, and decreased IL-6 expression, providing an improvement of nephritis [144]. This evidence concerns the gene MTOR and glioblastoma.