Network pharmacology analysis pinpointed five genes (STAT3, MAPK1, ESR1, PIK3R1, NFKB1) as potential targets of bioactive compounds, with particular emphasis on PIK3R1 due to its interaction with the insulin receptor (INSR) and its critical role in insulin signal transduction in T2DM. The gene discussed is PIK3R1; the disease is type 2 diabetes mellitus.