-Takes part in the transformation of cancer cells into stem cancer cells; stimulates their growth, proliferation, and evasion of growth suppressors.-Stimulates angiogenesis by increasing the content and transmission of VEGF-mediated signaling [249].-Provides resistance of cancer cells to anoikis through a mechanism involving fibronectin and αv/FAK integrin receptor signaling [250]. Here, FN1 is linked to cancer.