So, tumor cells constantly produce different growth factors such as transforming growth factor-beta1 (TGF-β1) and stromal cell-derived factor-1 (SDF1), interleukin (IL) 1β, platelet-derived growth factor A (PDGF-A), and fibroblast-activating protein and platelet-derived growth factor, which can facilitate the transformation of progenitor cells or NFs into CAFs [97,98,99] (Figure 2) [100,101]. This evidence concerns the gene CXCL12 and neoplasm.