HNSCC tumor cells produce IL-6, CXCL8, and epidermal growth factor (EGF), which improve the survival and angiogenic potential of endothelial cells through the activation of the STAT3/protein kinase B (AKT)/extracellular signal-regulated kinase (ERK) signaling pathways [50]. Here, IL6 is linked to head and neck squamous cell carcinoma.