Since the cytokine profile correlates with the clinical onset of CRS, the diagnostic process of severe CRS necessitates estimation of IL-6, IL-10, with some researchers proposing to also verify interferon-γ (IFN-ɣ), tumor necrosis factor-alpha (TNF-ɑ), and/or IL-5 levels [116,117]. The gene discussed is TNF; the disease is congenital rubella syndrome.