Through a comprehensive analysis of the sequence data, we meticulously annotated 26 BC susceptibility genes, namely, ATM, BARD1, BRCA1, BRCA2, BRIP1, CASP8, CDH1, CDKN2A, CHEK2, EPCAM, HMMR, MLH1, MSH2, MSH6, MUTYH, NBN, NF1, PALB2, PHB1, PMS2, PTEN, RAD51C, RAD51D, RAD54L, STK11, and TP53, spanning genes associated with low to high risk. The gene discussed is MSH6; the disease is breast cancer.