Tanaka et al. [120] managed to obtain HNSCC organoids that were as close as possible to the primary tumor; they had a similar morphology, and retained the expression of markers of mesenchymal (vimentin) and tumor (CD44 and ALDH1A1) cells, although CD68+ cells were found only in the tumor, but not in the organoids. This evidence concerns the gene ALDH1A1 and neoplasm.