VWF and acquired von willebrand syndrome: It seems to be associated with several dysfunctions in the coagulation cascade and in platelet adhesion and functioning, in particular: reduced platelet count, adhesion, and aggregability; reduced values of vWF (i.e., acquired von Willebrand syndrome), FVIII, FIX, and factor XI (FXI), reduced fibrinogen, and increased fibrinolysis [67,68].