CD4 and tuberculosis: Intracellular cytokine (IFN-γ, IL-2, and TNF-α) production by CD4+ and CD8+ T cells from Ugandan children with confirmed TB, unconfirmed TB, non-TB LRTI, and adults with confirmed TB, in response to Mtb-specific antigens ESAT-6 and CFP-10 (EC) was assessed by flow cytometry (Supplemental Figure S1).