Reported significance associated with increased mortality was more frequently observed in advanced age, male sex, low BMI, hypoalbuminemia, decreased lung function, respiratory comorbidities including Aspergillus co-infection, cavity, FC pattern, PPFE, and CRP level, whereas no statistical significance was observed in decreased ESM, diabetes mellitus, malignancy, NB pattern, bronchiectasis, consolidation, and smear grade with a small number of studies in each variable (Table 2). This evidence concerns the gene CRP and coinfection.