AKT1 and liver cancer: Likewise, downregulation of circRNA_10156, a circRNA highly expressed in HBV-related liver cancer [73], involved in the circRNA_10156/miR-149-3p/AKT1 signalling pathway [73], leads to increased expression of miR-149-3p, thereby depleting the expression of Akt1 and preventing the proliferation of liver cancer cells [73].