To further verify the effect of palmatine in a more physiological setting, PS2APP AD model mice expressing mutant presenilin 2 (PS2 N1411) and mutant amyloid precursor protein (APP Swe) were treated with palmatine (10 mg/kg) daily for 4 weeks and cognitive function was assessed using the Morris water maze test (Figure 5A). This evidence concerns the gene PSEN2 and Alzheimer disease.