The expression of MYC proto-oncogene, as well as bHLH transcription factor (MYC) and its target, snail family transcriptional repressor 1 (SNAI1), is inhibited when circ-TNPO3 sequesters IGF2BP3, which reduces the ability of gastric cancer cells to proliferate and metastasize [84]. The gene discussed is MYC; the disease is gastric cancer.