Obviously, DM is the first example we think of; however, this syndrome involves a myriad of different conditions, including: (1) varying levels of plasma glucose, insulin, and other metabolic or hormonal substrates (such as lipids, proteins, glucagon, and cortisol, etc.), (2) a varied production of advanced glycated end products (AGEs), (3) different grades of oxidative, inflammatory, and endoplasmic reticulum stress, and (4) the time of evolution of the disease. This evidence concerns the gene INS and diabetes mellitus.