Moreover, like the well-established pivotal role of GLUT4 in peripheral insulin-stimulated glucose uptake, and the relationship with metabolic diseases [40], it is now clear that GLUT4 also plays a fundamental role in the metabolic homeostasis of hippocampal neurons, which can also play a role in diseases related to impaired neuronal homeostasis [81]. The gene discussed is SLC2A4; the disease is Other metabolic disease.