MYD88 and pulmonary fibrosis: They showed that MyD88 is crucial for the development of inflammation and granulomas following silica exposure, whereas pulmonary fibrosis in MyD88−/− mice was associated with the accumulation of profibrotic regulatory T lymphocytes, IL-17-producing Th17 lymphocytes, and profibrotic cytokines such as TGF-β, IL-10, and PDGF-B) [68].