In particular, alterations in the family members CDH1 and CDH3 have been reported to be associated with malignant transformation of various tissues and the progression of a variety of cancers, such as HCC, adenocarcinoma of the gall bladder, pancreas, colon and rectum, breast, urinary bladder, and prostate [21,26,27,28,29,30,31]. The gene discussed is CDH3; the disease is gallbladder adenocarcinoma.