To corroborate the data of these loss-of-function screenings, we used shRNA-dependent knockdown of MEN1 in four B-ALL cell lines: NALM6 (ETV6-PDGFRB), SUP-B15 (BCR-ABL1), and the MLLr cell lines RS4;11 (MLL-AF4) (Figure 2) and KOPN8 (MLL-ENL) (Figure 3). Here, KMT2A is linked to acute lymphoblastic leukemia.