Genes related to rs117719091 (PFKFB3) and rs140233124 (KIAA0232) play crucial roles in cancer metabolism; PFKFB3 induces glycolysis and activates hepatic stellate cells and then promotes liver fibrosis [29,30], and KIAA0232 stimulates insulin secretion to regulate cancer metabolism [31,32]. This evidence concerns the gene PFKFB3 and cancer.