For MHC class II, DPA1, DPB1, DQA1, DQB1, and DRB1 were associated with the development of HBV infection, HCV infection, or HCC, including DPA1*01:03 (p = 9.95 × 10−5, OR = 1.13, 95% CI = 1.06–1.2) and DPA1*02:02 (p = 8.18 × 10−5, OR = 0.9, 95% CI = 0.85–0.95) for HCC (Table S7.10), DPA1*01:03 (p = 1.30 × 10−86, OR = 1.4, 95% CI = 1.35–1.45) and DPA1*02:02 (p = 2.24 × 10−88, OR = 0.73, 95% CI = 0.71–0.76) for HBV infection (Table S7.11), and DPA1*01:03 (p = 1.29 × 10−2, OR = 0.94, 95% CI = 0.9–0.99) and DPA1*02:02 (p = 4.52 × 10−2, OR = 1.04, 95% CI = 1–1.09) for HCV infection (Table S7.11). This evidence concerns the gene HLA-DRB1 and hepatocellular carcinoma.