For group 1, seven of the thirteen novel-loci-related coding or noncoding genes, namely F11/F11-AS1, PFKFB3, PRMT8, FAM66C, NAV2/NAV2-AS1, FRMD4A, and KIAA0232, have been demonstrated to be correlated with the development of HCC or other cancers in many studies. The gene discussed is PFKFB3; the disease is hepatocellular carcinoma.