For group 2, the loci-related genes HLA-DPA2, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DQB3, and COL11A2P1, were determined to be associated with HCC in the Taiwanese patients enrolled in this study but not in the UK Biobank and BBJ participants. Here, HLA-DQB3 is linked to hepatocellular carcinoma.