Mposhi et al. and Pirola et al. reported that the mitochondrial ND6 region, an essential component of Complex I of the OXPHOS cycle, is hypermethylated and downregulated in cell lines overexpressing a mitochondrial targeted CpG-specific DNMT (MSssI) or a GpC-specific DNMT (MCviPI) and MASH patients compared to patients with steatosis [21,26]. Here, DNMT1 is linked to steatosis.