AKT1 and cancer: We have particularly focused on the results showing that sorafenib-resistant PTC was greatly stimulated by calcium, and cancer stemness involved the following signaling pathways (calcium, Notch, Wnt, PPAR, PI3K/Akt, and TGF/SMAD) than sorafenib-sensitive PTC (Figure 1C, top and bottom) in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis [28,29,30,31,32].