Recent studies have demonstrated that PGC-1α protects against neuroinflammation and performs a neuroprotective influence in neurodegenerative diseases and, therefore, plays a critical role in the pathophysiology of many neurodegenerative disorders [62,63], which may participate in the clinical presentation of a neurodevelopmental disorder with ataxia and oculomotor apraxia. Here, PPARGC1A is linked to Oculomotor apraxia.