PPARGC1A and neurodegenerative disease: Recent studies have demonstrated that PGC-1α protects against neuroinflammation and performs a neuroprotective influence in neurodegenerative diseases and, therefore, plays a critical role in the pathophysiology of many neurodegenerative disorders [62,63], which may participate in the clinical presentation of a neurodevelopmental disorder with ataxia and oculomotor apraxia.