AKT1 and infection: Similarly, downregulated miRs involved with T-cell receptor signaling in the 8-week infection group were associated with MAPK signaling pathways, calcium signaling pathways, osteoclast differentiation signaling pathway, PI3K-Akt signaling pathways, NF-κB signaling pathways, cell adhesion molecules, and ubiquitin-mediated proteolysis genes (Figure 3B and Figure S1).