The potential role of the Tff3 gene in a metabolism-related condition called diabesity (a combination of diabetes and obesity) was first revealed by quantitative trait locus (QTL) analysis of a mouse model of diabetes, the Tally Ho mouse strain [14], in which the complete reduction of Tff3 in the liver was the most dramatic change in early diabetes. Here, TFF3 is linked to obesity due to melanocortin 4 receptor deficiency.