The aim of our study was to observe the ST6GAL1 protein expression in papillary thyroid cancer (including follicular variant and microcarcinoma) and in follicular thyroid cancer, as well as to analyze the ST6GAL1 mRNA levels in a larger thyroid cancer cohort retrieved from The Cancer Genome Atlas (TCGA) database. This evidence concerns the gene ST6GAL1 and thyroid gland papillary carcinoma.