Among these 215 signaling pathways, the hsa04151: PI3K-Akt signaling pathway is responsible for growth, cell proliferation, and metabolism [47], which was reported by other researchers who found that through decreased AKT and FAK activation, PIK3CA knockdown significantly decreases cell survival, migration, and invasion of GBM cell [48]. The gene discussed is AKT1; the disease is glioblastoma.