VEGFA and neoplasm: HIF2α-triggered target factors include VEGF-α [60,65], TGF α/EGFR [66], c-Myc [60,67,68], cyclin D1 [69,70], SLC7A5-mTorC1 [60,71,72], GLUT1 [73,74], antioxidant enzymes [75], mitochondrial biogenesis factors [76], GAS6/tyrosine kinase AXL [77] and CXCR4/SDF1 [78], which control critical biological activities such as tumour angiogenesis, cell-autonomous proliferation, increasing glycolysis, resistance to oxidative damage, endoplasmic reticulum stress and metastatic ability [60,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81].