Signalling between chemokines and their receptors regulates tumour cell settlement in host organs e.g., by recruitment of MDSCs, TAMs, Tregs and tumour-associated neutrophils into distant secondary sites, and thus, supporting the formation of the premetastatic niche [162,163], or in supporting cancer by stepwise activating the pluripotency regulator transcription factors OCT4, NANOG and SOX2, whose activation helps cancer cells in attaining stemness properties [176,178]. The gene discussed is POU5F1; the disease is cancer.