Since the formation of pMN results from the interaction of primary tumour-derived components (tumour-derived secreted factors including VEGF, TNF-α, TGF-β, G-CSF and tumour-derived extracellular vesicles (EV) like, exosomes, microvesicles containing a variety of proteins, mRNAs, miRNAs and signalling molecules) with tumour-mobilised bone-marrow-derived cells (MDSC, TAM) and the local microenvironment [163,164,165,166,167,168,169,170,171,172,173,174,175], this is associated with organotropism, which is a characteristic of pMN [163]. This evidence concerns the gene TNF and neoplasm.