Importantly, ADNFLE and nocturnal frontal lobe epilepsy (NFLE) phenotypes related to KCNT1 mutations tend to be more severe, with refractory seizures and a higher prevalence of intellectual disability or psychiatric features when compared to ADNFLE caused by mutations in the CHRNA4 and CHRNB2 genes encoding for neuronal nicotinic receptor subunits (alpha4 and beta2, respectively). Here, CHRNA4 is linked to autosomal dominant nocturnal frontal lobe epilepsy.