It is known that Dravet syndrome can be a result of mutations in genes encoding the α1, β1, β2, and γ2 subunits of GABAARs. A de novo mutation of the β1(F246S) subunit was detected in a patient with infantile spasms, while a de novo mutation in exon 4 of GABRB2 (β2(M79T)) was identified to cause intellectual disability and epilepsy [82,83,84,85,86].Epilepsy treatment with benzodiazepines or barbiturates, non-specific positive allosteric modulators of GABAA Rs, is quite effective. This evidence concerns the gene GABRB2 and epilepsy.