Astragalus polysaccharide (APS) has been shown to reduce the levels of ROS, MDA, and NO in diabetic cardiomyopathy (DCM) cell models, improve the activity of antioxidant enzymes, and promote the proliferation of DCM cells, thus playing a protective role in DCM cells, which may be related to the activation of the NGR1/ErbB signaling pathway by APS [63]. Here, RTN4R is linked to familial dilated cardiomyopathy.