HAND2 and Hyperglycemia: In these Islet 1-positive (Isl1+) multipotent progenitor cells, maternal hyperglycemia induced differential expression of genes encoding TFs regulating cell lineage specification (Insulin Gene Enhancer Protein (Isl1), Tbx1, Tbx20, Fibroblast growth factor 10 (Fgf10), Myocyte enhancer factor 2C (Mef2c), Nkx2.5, and Heart And Neural Crest Derivatives Expressed 2 (Hand2)), thus contributing to CHDs [77].