Furthermore, pathological variants in genes encoding chromatin-remodeling enzymes have been found in CHD patients, including Chromodomain-Helicase-DNA-Binding Protein 7 (CHD7), Lysine (K)-Specific Methyltransferase 2D (KMT2D), Lysine Acetyltransferase 6A (KATA6A), Lysine Acetyltransferase 6B (KATA6B), Nuclear Receptor-Binding SET-Domain Protein (NSD1), Chromodomain-Helicase-DNA-Binding Protein 4 (CHD4) [28], suggesting a crucial role of epigenetic regulations in normal heart development. The gene discussed is CHD4; the disease is coronary artery disorder.