MiR-148a-3p decreases tau hyperphosphorylation at Ser202/Thr205, Ser199, Ser396, and Ser404 by targeting cyclin-dependent kinase 5 regulatory subunit 1 (CDK5R1) mRNA, which encodes the p35 protein, and intracerebroventricular injections of miR-148a-3p ameliorate cognitive deficits in AD model mice [69]. The gene discussed is MAPT; the disease is Alzheimer disease.