BCL2 and hepatocellular carcinoma: In Adriamycin-resistant HCC HepG2/ADM cells, the pro-survival protein Bcl-2 and the JNK2 pathway are overexpressed, and treatment with Bcl-2 inhibitors, such as ABT-737 or Apogossypolone, induces ROS and Beclin1 mediated protective autophagy by releasing Beclin1 from the cytoplasmic Beclin1/Bcl-2 complex [141].