SH2B3 and polycystic ovary syndrome: The expression of LNK in granulosa cells of PCOS mice is significantly upregulated, and a high concentration of LNK activates the AKT-FOXO3 signaling pathway and inhibits the transfer of FOXO3 from the nucleus to the cytoplasm, activates insulin resistance and granulosa cell apoptosis, and leads to the downregulation of glucose metabolism [134].