Primary skin fibroblasts from a PD patient with a heterozygous parkin mutation and a healthy subject from the same family (control) were isolated from skin biopsy and cultured under suitable conditions. Then, the cells were treated with resveratrol (25 μM) or vehicle alone (0.2% DMSO). Proteomic analysis was performed using 2-DE, MALDI-TOF-MS, and Western blot. This evidence concerns the gene PRKN and Parkinson disease.