LRRK2 and Parkinson disease: Lapatinib improved motor deficits in ROT-induced rats and reduced nigrostriatal dopaminergic depletions. Reduction in HSP90, CDC37, and c-SRC levels resulted in neuroprotective effects in ROT-induced rats by suppressing the main proteins involved in PD pathogenesis (α-syn, LRRK2, and c-ABL).