Moreover, SIRT1 deacetylates FoxO proteins and thus stimulates FoxO-dependent antioxidative enzymes, such as catalase (CAT), manganese superoxide dismutase (MnSOD), and thioredoxin (TRX), eliminating ROS from endothelial cells and thus preventing endothelial dysfunction [132,133,134,135]. The gene discussed is SOD2; the disease is endothelial dysfunction.