PPARG and Hypertension: Finally, on a rat model of LPS-induced PE, a transplant of human mesenchymal stem cells (MSC) resulted in reduced activity of pro-inflammatory mediators, such as IL-6 and TNF-α, as well as increased placental PPARγ activity; this was accompanied by a milder course of arterial hypertension and greater fetal mass in comparison with rats treated with LPS alone [113].