Glioma-derived factors, such as IL-1β, IL-6, IL-8, and TNFα, are crucial inflammatory mediators that trigger the inflammatory cycle in GBM and also promote carcinogenesis by avoiding growth suppression and apoptosis, inducing angiogenesis and metastasis and maintaining cancer cell stemness [23,43]. The gene discussed is CXCL8; the disease is central nervous system cancer.